Transgenic animals in cardiovascular disease research
نویسندگان
چکیده
منابع مشابه
transgenic animals in pharmaceutical and biological research in iran
transgenic (tg) mice are very important models of disease, and have been introduced to biological studies since 1982. they are used for understanding the pathobiology of different diseases, finding targets for pharmacological manipulations, and for the evaluation of efficacy and toxicity of medicines in preclinical studies. many different types of tg mice are available as models for human disea...
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We have shown that it is possible to generate transgenic rats efficiently, allowing direct experimentation in this species, without first testing constructs in the mouse. Having developed the technology for producing transgenic rats, we now hope to generate new and precise models of hypertension and to test candidate genes that may be responsible for the phenotype in existing animal models. The...
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Transgenic (Tg) mice are very important models of disease, and have been introduced to biological studies since 1982. They are used for understanding the pathobiology of different diseases, finding targets for pharmacological manipulations, and for the evaluation of efficacy and toxicity of medicines in preclinical studies. Many different types of Tg mice are available as models for human disea...
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The technique of introducing new genetic material into the germline of mammals has been a major development in biotechnology over the last decades. ”Transgenic animals“ are animals whose chromosomes contain stable, integrated copies of exogenous genes, additional copies of endogenous genes or gene constructs. They are frequently created by two different techniques: microinjection of DNA into th...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2000
ISSN: 0958-0670
DOI: 10.1017/s0958067000020960